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Human Papiloma Virus HPV

Human Papillomavirus

Human Papillomavirus  HPV treatment Human Papilloma Virus or HPV is a DNA (deoxyribonucleic acid) virus.
HPV virus carries genetic information. Molecular biology techniques deciphered the genetic code of most HPV virus and its relation with aggressiveness and human body locations of the infections.

DNA is like a program that every cell of the human body has. It contains all the information that give us our physical appearance, individual and unique characteristics. The same goes for Human Papilloma Virus (HPV).
More than 100 types of HPV have been discovered. They differ in their DNA which make HPV more or less aggressive, infect the body in different locations,  give them a causal relation with Cervical Cancer, other types of cancer, skin and mucosal epithelium diseases,  or simple genital warts.

HPV is a DNA virus that affects only humans.

P= Papilloma                                                                                         

Human Papilloma Virus or HPV virus belongs to the family of papovavirus. Papovavirus are divided in two genera, type A and type B. Type A papovavirus do not induce infections in other species than humans and can not be cultivate. Their only host are humans.
Type B papovavirus does not affect humans and can be cultivate. They are important as a laboratory model.
Human papilloma virus or HPV virus are characterized by having a small diameter. Viral particles are identical by the electron microscope view, they differ only in their DNA.  More than hundred types of HPV have been discovered and new types are being discovered continually.
Many of the subtypes found are related to infections in male and female genitalia.
HPV virus infections are related with the genesis or development of some carcinomas of the female genitals, penis, anus, mouth, cutaneous carcinomas associated or not with skin warts. Depending on the subtype, HPV is a cancer cause.  
HPV genital infection is considered a sexually transmitted disease. Other transmission routes are possible, also the spread of mother to child during birth.

Drs. Herald Zur Hausen research was the first to establish a relation between HPV and genital cancer.
HPV (Human Papillomavirus) infection can persist many years, but also it is possible a self-limiting process with HPV disappearance defeated  by the body's defenses.
HPV genital infection has three stages, a latent stages were HPV (Human Papillomavirus) can only be diagnosed by DNA techniques, a subclinical stage were HPV can be detected by DNA techniques and the use of  some instruments like camera,  colposcopy, etc. The third stage or clinical stage permits us to see HPV lesions by the naked eye.

The certain diagnose most be done by molecular biology.
Using molecular pathology techniques, the HPV test, unlike the Pap smear, allows us to have a precise diagnosis of the Human Papillomavirus. The Polymerase Chain Reaction (PCR) is a painless technique which involves the extraction of cellular material as it is done in a Pap smear but, unlike this, it has a sensitivity of 100% in the cervix. In other words, there is no possibility of false negatives if the extraction is correctly performed. This molecular biology technique, which we prefer and recommend, also gives us the possibility to find out which type of HPV the patient actually has. The importance of this lies in the fact that there are tumor viruses, in other words, viruses related to cancer such as: HPV 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 and 68, among others. There are other viruses related to benign warts which may result unsightly or contagious. This technique is also used in other genital areas such as the vagina, vulva, anus, penis or other parts of the body, which cannot be contagious, such as the mouth or areas of the skin near the genitals and different organs where the HPV infections are less frequent, on the other hand PCR lets us know if HPV vaccines will be preventive or not
Another currently used technique for detection of the HPV is the “hybrid-capture” test which gives us the possibility to obtain information about the human papillomaviruses connected to genital infection or cervix cancer as well as some benign viruses related to common warts. Unlike PCR, this technique does not report on the infectious type of viruses and it is only sensitive to the most frequently found viruses.
The “hybrid-capture” detects HPV viruses which are often found in the genitals. These one are classified in: Group I: 6, 11, 42, 43, 44, 53 and 54 called “low-risk” HPV types and which are not related to cancer; and Group II viruses, also called of “high-risk”: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 and 68 related cancer.
HPV (Human Papillomavirus), can be considered a transforming agent thus called tumoral viruses.
Tumoral viruses such as some types of HPV cause the transformation of a normal into a cancerous cell. This is a result of HPV  ability to integrate its genetic information (HPV DNA) into the nuclear DNA of the host cell. Some HPV oncoproteins play an important role in this transformation.

  • HPV or Human Papillomavirus is a DNA virus. Each type of HPV has his one and individual genetic characteristics.
  • HPV or Human Papillomavirus is a virus that infects humans only.
  • HPV or human papillomavirus has many genetic variants and there are more than hundred types discovered by molecular pathology.
  • HPV or human papillomavirus can induce the transformation of a normal cell into a cancer cell.
  • HPV or Human Papillomavirus is fundamentally related to cervical, vagina, vulva, anus, penis, mouth, airways, skin and others types of cancer.
  • HPV or Human Papilloma Virus can be diagnosed early on by DNA techniques (PCR and Hybrid Capture).
  • HPV or Human Papilloma Virus also can be detected by Pap smear and Colposcopy but usually when it is already in advanced stages 

Human Papiloma Virus HPV VPH

Human Papiloma Virus HPV VPH HPV treatment


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The Human Papiloma Virus VPH  is a DNA Virus. More than 100 types of HPV VPH  have been detected by Molecular Biology and many of them(aproximately 30 types) are related to Feminine and Masculine Genitalia infections.

Each HPV Virus has his own DNA information with individual characteristics, that make HPV more or less agressive for Human Body, being some of them related to different types of cancer.

Human Papiloma Virus ( VPH  Virus) infects the skin and mucouse membranes. It is estimated that 60% of men and woman will get a genital HPV infection at some point in their lives.  HPV VIRUS infections are spread Through genital contact.(sexual intercourse)

According to Molecular Biology technics (Protein Chain Reaction, PCR) HPV Virus qualify in two groups for Femenine Genitalia infections, the first one(called low risk types of HPV or non Tumoral HPV viruses) related to benign Genital Warts and the second group(called high risk or tumoral HPV VPH  viruses) to pre-malignant or malignant (Cervival Cancer, and others)lesions and Genital Warts also.

DNA Technologies, PCR (More used in our Medical Institute) and Hibrid Capture  permit us an early and accurate detection of HPV VPH  in the uterine cervix with 100% sesibility.

Protein Chain Reaction (PCR) is also specific to detect the type of HPV VPH  responsable for the infection.

HPV VPH  is also cause of pre-malignant and malignant Penis, Vaginal, Vulvar, Anal, Oral Cavity, etc, lesions, depending on the type of HPV VPH  that is infecting.

Inmune system fights off HPV VPH  VIRUS in  most of infected patients, but in some of them a persisting infection can couse, normal cells, to become abnormal.

Big differences were observed between results obtaind to detect HPV VPH  by PAP (Papanicolaou) Smears only, and PCR or Hibrid Capture.

PCR and HIBRID CAPTURE (HPV VPH  TEST) are highly top for an early and preventive diagnosis of HPV VPH  infections.

The main goal of this page is trying to explain the importance of doing HPV VPH  TEST (PCR or Hibrid Capyure) as a rutin exam with Pap Smear and colposcopy to prevent cervical, an other types of cancer, detecting HPV VPH  VIRUS in early stages.