There are over one hundred viral subtypes that differ in their DNA. Some of these subtypes like HPV (VPH) 16 are associated with precancerous and cancerous lesions in different parts of the body. Other viral types that have been associated with cancerous lesions are HPV (VPH) 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68 and others. HPV (VPH) has been attributed as the cause of Cervical Cancer.
HPV (VPH) is also linked to vaginal, vulvar, penis, anus, mouth, among others.
HPV (VPH) penetrates the nucleus of normal cells inducing malignant transformation.
Not all HPV (VPH) infections will become a Cancer. Often, HPV (VPH) lesions disappear alone by the host immunologic system or the performed treatment techniques to the patient.
The subtypes 6, 11, 42, 43 and 44 are related to benign genital warts in female and male genital tract, whereas HPV (VPH) 16, 18, 31, 33, 35, 39, 45, 51 , 52, 56, 58, 59 and 68 are related to female and male genital cancer and others.
Skin warts are generally associated with subtypes 2 and 7, feet warts with subtypes 1, 2, 3 and 4, flat skin warts with subtypes 3 and 10. Mouth injuries are often associated with subtypes 6, 7, 11, 13, 16, 32 and others. Epidermodysplasia verruciformis is associated with more than 15 different subtypes.
The certain diagnose most be done by molecular biology.
Using molecular pathology techniques, the HPV (VPH) test, unlike the Pap smear, allows us to have a precise diagnosis of the Human Papillomavirus. The Polymerase Chain Reaction (PCR) is a painless technique which involves the extraction of cellular material as it is done in a Pap smear but, unlike this, it has a sensitivity of 100% in the cervix. In other words, there is no possibility of false negatives if the extraction is correctly performed. This molecular biology technique, which we prefer and recommend, also gives us the possibility to find out which type of HPV (VPH) the patient actually has. The importance of this lies in the fact that there are tumor viruses, in other words, viruses related to cancer such as: HPV (VPH) 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 and 68, among others. There are other viruses related to benign warts which may result unsightly or contagious. This technique is also used in other genital areas such as the vagina, vulva, anus, penis or other parts of the body, which cannot be contagious, such as the mouth or areas of the skin near the genitals and different organs where the HPV (VPH) infections are less frequent, on the other hand PCR lets us know if HPV (VPH) vaccines will be preventive or not .
Another currently used technique for detection of the HPV (VPH) is the “hybrid-capture” test which gives us the possibility to obtain information about the human papillomaviruses connected to genital infection or cervix cancer as well as some benign viruses related to common warts. Unlike PCR, this technique does not report on the infectious type of viruses and it is only sensitive to the most frequently found viruses.
The “hybrid-capture” detects HPV (VPH) viruses which are often found in the genitals. These one are classified in: Group I: 6, 11, 42, 43, 44, 53 and 54 called “low-risk” HPV (VPH) types and which are not related to cancer; and Group II viruses, also called of “high-risk”: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 and 68 related cancer.
HPV (VPH) (Human Papillomavirus), can be considered a transforming agent thus called tumoral viruses.
Tumoral viruses such as some types of HPV (VPH) cause the transformation of a normal into a cancerous cell. This is a result of HPV (VPH) ability to integrate its genetic information (HPV (VPH) DNA) into the nuclear DNA of the host cell. Some HPV (VPH) oncoproteins play an important role in this transformation.
"DNA test for HPV (VPH) detection (PCR and Hybrid Capture.) HPV (VPH) in women, HPV (VPH) in man. HPV (VPH) TEST, Pap smear, Colposcopy. Importance of and early diagnosis of HPV (VPH). HPV (VPH) and Cancer. Treatment of HPV (VPH). Low and high grade SIL . CIN 1, CIN 2, CIN 3, in situ carcinoma and its relation with HPV (VPH). Different types of treatments for HPV (VPH) leep, laser, cryosurgery, endocoagulation, interferon, podophyllotoxin, other medical HPV (VPH) treatments. Relation between cervical, vaginal, vulvar, penis, anus, rectum, mouth, skin cancer and HPV (VPH). HPV (VPH) in pregnanHuman Papilloma Virus or HPV (VPH) is the cause of Cervical cancer in women, recommendations. HPV (VPH) in the newborn child. HPV (VPH) vaccine". the second in frequency after breast cancer. Human papillomavirus is also related to vaginal, vulvar, anus, rectum, penis, skin and mouth cancer, depending on the subtype of HPV (VPH) that is infecting.